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新生儿脑电图中完整电极模型的正向和反向效应

Forward and inverse effects of the complete electrode model in neonatal EEG.

作者信息

Pursiainen S, Lew S, Wolters C H

机构信息

Department of Mathematics, Tampere University of Technology, Tampere, Finland;

Newborn Medicine in the Boston Children's Hospital, Boston, Massachusetts.

出版信息

J Neurophysiol. 2017 Mar 1;117(3):876-884. doi: 10.1152/jn.00427.2016. Epub 2016 Nov 16.

Abstract

This paper investigates finite element method-based modeling in the context of neonatal electroencephalography (EEG). In particular, the focus lies on electrode boundary conditions. We compare the complete electrode model (CEM) with the point electrode model (PEM), which is the current standard in EEG. In the CEM, the voltage experienced by an electrode is modeled more realistically as the integral average of the potential distribution over its contact surface, whereas the PEM relies on a point value. Consequently, the CEM takes into account the subelectrode shunting currents, which are absent in the PEM. In this study, we aim to find out how the electrode voltage predicted by these two models differ, if standard size electrodes are attached to a head of a neonate. Additionally, we study voltages and voltage variation on electrode surfaces with two source locations: ) next to the C6 electrode and ) directly under the Fz electrode and the frontal fontanel. A realistic model of a neonatal head, including a skull with fontanels and sutures, is used. Based on the results, the forward simulation differences between CEM and PEM are in general small, but significant outliers can occur in the vicinity of the electrodes. The CEM can be considered as an integral part of the outer head model. The outcome of this study helps understanding volume conduction of neonatal EEG, since it enlightens the role of advanced skull and electrode modeling in forward and inverse computations. The effect of the complete electrode model on electroencephalography forward and inverse computations is explored. A realistic neonatal head model, including a skull structure with fontanels and sutures, is used. The electrode and skull modeling differences are analyzed and compared with each other. The results suggest that the complete electrode model can be considered as an integral part of the outer head model. To achieve optimal source localization results, accurate electrode modeling might be necessary.

摘要

本文研究了基于有限元法的新生儿脑电图(EEG)建模。特别关注的是电极边界条件。我们将完整电极模型(CEM)与点电极模型(PEM)进行了比较,点电极模型是目前EEG的标准模型。在CEM中,电极所经历的电压被更真实地建模为其接触表面上电位分布的积分平均值,而PEM则依赖于一个点值。因此,CEM考虑了子电极分流电流,而PEM中不存在这种电流。在本研究中,我们旨在找出如果将标准尺寸的电极附着在新生儿头部,这两种模型预测的电极电压有何不同。此外,我们研究了两个源位置处电极表面的电压和电压变化:)在C6电极旁边和)直接在Fz电极和前囟下方。使用了一个逼真的新生儿头部模型,包括带有囟门和缝线的颅骨。基于结果,CEM和PEM之间的正向模拟差异总体较小,但在电极附近可能会出现显著的异常值。CEM可被视为外部头部模型的一个组成部分。这项研究的结果有助于理解新生儿EEG的体积传导,因为它揭示了先进的颅骨和电极建模在正向和反向计算中的作用。探讨了完整电极模型对脑电图正向和反向计算的影响。使用了一个逼真的新生儿头部模型,包括带有囟门和缝线的颅骨结构。分析并比较了电极和颅骨建模的差异。结果表明,完整电极模型可被视为外部头部模型的一个组成部分。为了获得最佳的源定位结果,可能需要精确的电极建模。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe1d/5338621/a6c1c7d455aa/z9k0021739910001.jpg

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