Kaufmann S H
Max-Planck-Institut für Immunobiologie, Freiburg, Federal Republic of Germany.
Rev Infect Dis. 1989 Mar-Apr;11 Suppl 2:S448-54. doi: 10.1093/clinids/11.supplement_2.s448.
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis. Protection against and pathogenesis of tuberculosis greatly depend on specific T lymphocytes, and it is generally assumed that CD4+ T cells--through lymphokine-mediated macrophage activation--are the major mediators of the host response to tuberculosis. In the present report, results from experimental tuberculosis studies in mice are summarized which indicate that both CD4+ and CD8+ T lymphocytes are generated during tuberculosis. Furthermore, evidence is presented that both T cell populations are involved in protection against and pathogenesis of tuberculosis and that the final outcome of the host response depends on an intricate balance between these two types of T cells.
结核病是一种由结核分枝杆菌引起的慢性传染病。对结核病的防护和发病机制在很大程度上取决于特定的T淋巴细胞，人们普遍认为，CD4+ T细胞——通过淋巴因子介导的巨噬细胞激活——是宿主对结核病反应的主要介质。在本报告中，总结了小鼠实验性结核病研究的结果，这些结果表明在结核病过程中会产生CD4+和CD8+ T淋巴细胞。此外，有证据表明这两种T细胞群体都参与了对结核病的防护和发病机制，并且宿主反应的最终结果取决于这两种T细胞之间复杂的平衡。
