Rooney I A, Oglesby T J, Atkinson J P
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Immunol Res. 1993;12(3):276-94. doi: 10.1007/BF02918258.
The behaviour of the complement system during human reproduction is now the focus of much scientific attention. The presence of antisperm antibodies in the reproductive tracts of some infertile individuals, and of complement in cervical and ovarian follicular fluid, suggests that complement-mediated damage of spermatozoa is involved in some cases of infertility. Further, deposition of maternal IgG and of complement in the extrafetal tissues indicates that complement activation occurs within the fetoplacental unit. Recently, three complement-regulatory proteins--decay-accelerating factor, membrane cofactor protein and CD59--have been detected on spermatozoa and in the extrafetal tissues. It is likely that these inhibitors are essential for normal reproductive function. This article reviews current understanding of the interaction of the complement system with cells and tissues involved in reproduction, with emphasis on the nature and function of the controlling proteins.
补体系统在人类生殖过程中的行为现已成为众多科学关注的焦点。一些不育个体生殖道中存在抗精子抗体，以及宫颈和卵泡液中存在补体，这表明补体介导的精子损伤在某些不育病例中起作用。此外，母体 IgG 和补体在胎儿外组织中的沉积表明补体激活发生在胎盘胎儿单元内。最近，在精子和胎儿外组织中检测到三种补体调节蛋白——衰变加速因子、膜辅因子蛋白和 CD59。这些抑制剂可能对正常生殖功能至关重要。本文综述了目前对补体系统与生殖相关细胞和组织相互作用的理解，重点关注调控蛋白的性质和功能。
