De Weer P
Respir Physiol. 1978 Apr;33(1):41-50. doi: 10.1016/0034-5687(78)90082-8.
Experiments are reviewed in which intracellular pH (pHi), during exposure of a cell to CO2- or NH3-containing solutions, not only undergoes an acidification of alkalinization, respectively, but tends to return toward its original value and, upon removal of the test solution, rebounds to a value more alkaline or acid, respectively, than the initial one. A simple physiochemical model is discussed which interprets these observations both qualitatively and quantitatively. In the case of NH3-induced transients, only passive movements seem to take place; in the CO2-induced transients one must postulate an active 'proton pump'. Experimentally verifiable predictions can be made from these models. It is suggested that many physiological effects follow exposure to CO2 or NH3 may be subject to similar transients and rebounds.
本文回顾了一些实验，在这些实验中，当细胞暴露于含二氧化碳或氨的溶液时，细胞内pH值（pHi）不仅会分别发生酸化或碱化，而且往往会趋向于恢复到其原始值，并且在去除测试溶液后，会分别反弹到比初始值更碱性或更酸性的值。文中讨论了一个简单的物理化学模型，该模型对这些观察结果进行了定性和定量的解释。在氨诱导的瞬变情况下，似乎只发生了被动移动；在二氧化碳诱导的瞬变情况下，则必须假定存在一个活跃的“质子泵”。从这些模型可以得出实验可验证的预测。有人提出，暴露于二氧化碳或氨后产生的许多生理效应可能会经历类似的瞬变和反弹。
