Parente V, Clark R H, Ku L, Fennell C, Johnson M, Morris E, Romaine A, Utin U, Benjamin D K, Messina J A, Smith P B, Greenberg R G
Department of Pediatrics, Duke University, Durham, NC, USA.
Pediatrix-Obstetrix Center for Research and Education, Sunrise, FL, USA.
J Perinatol. 2017 Feb;37(2):157-161. doi: 10.1038/jp.2016.201. Epub 2016 Nov 17.
The aim of this study was to identify risk factors for early-onset group B Streptococcus (EOGBS) disease in neonates of mothers with negative antenatal screening.
We performed a retrospective cohort study of neonates born to mothers with negative antenatal GBS screening between 2002 and 2012. Our primary outcome was EOGBS infection. We used multivariable logistic regression to assess factors associated with EOGBS.
EOGBS was confirmed in 492 of the 179 818 neonates that met the study inclusion criteria. Risk factors for EOGBS included black race (reference: white, odds ratio (OR) =1.81 (95% confidence interval: 1.43, 2.31)), maternal age <18 years (reference: >35 years, OR=2.63 (1.54, 4.51)) and maternal age 18 to 35 years (reference: >35 years, OR=1.94 (1.30, 2.88)).
Maternal age <18 years and black race were the strongest predictors of EOGBS. Further research investigating contributors to the discordance between screening results and neonatal outcomes in these populations is needed.
本研究旨在确定产前筛查阴性的母亲所生新生儿早发型B族链球菌（EOGBS）疾病的危险因素。
我们对2002年至2012年间产前GBS筛查阴性的母亲所生新生儿进行了一项回顾性队列研究。我们的主要结局是EOGBS感染。我们使用多变量逻辑回归来评估与EOGBS相关的因素。
在符合研究纳入标准的179818例新生儿中，492例确诊为EOGBS。EOGBS的危险因素包括黑人种族（参照：白人，比值比（OR）=1.81（95%置信区间：1.43，2.31））、母亲年龄<18岁（参照：>35岁，OR=2.63（1.54，4.51））以及母亲年龄18至35岁（参照：>35岁，OR=1.94（1.30，2.88））。
母亲年龄<18岁和黑人种族是EOGBS最强的预测因素。需要进一步研究调查这些人群中筛查结果与新生儿结局不一致的影响因素。
