Tian J Q, Wei E T
School of Public Health, University of California, Berkeley 94720.
Drug Chem Toxicol. 1989 Mar;12(1):61-6. doi: 10.3109/01480548908999143.
Increased vascular permeability, as measured by changes in skin weight and Evans blue dye extravasation, was produced in the skin after immersion of the anesthetized rat's paw in 12 N hydrochloric, 18N sulfuric, or 14N hydrofluoric acids for 2 min. Corticotropin-releasing factor (CRF), a 41-residue peptide having the rat/human sequence, injected 28 micrograms/kg i.v. 10 min before immersion, was efficacious in reducing these indices of skin injury.
通过皮肤重量变化和伊文思蓝染料外渗测量发现，将麻醉大鼠的爪子浸入12N盐酸、18N硫酸或14N氢氟酸中2分钟后，皮肤的血管通透性增加。促肾上腺皮质激素释放因子（CRF）是一种具有大鼠/人类序列的41个氨基酸残基的肽，在浸入前10分钟静脉注射28微克/千克，可有效降低这些皮肤损伤指标。
