Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
Br J Sports Med. 2017 Apr;51(8):636-639. doi: 10.1136/bjsports-2016-096710. Epub 2016 Nov 17.
The societal value of strategies that delay the onset and progression of dementia cannot be overstated. Physical activity-unstructured and structured-is a promising, cost-effective strategy for the promotion of brain health. However, a large degree of variation exists in its efficacy. Therefore, to increase its utility as 'medication' for healthy cognitive ageing, it is imperative to identify key moderators and mediators of the positive effects of targeted exercise training on brain health. In this commentary, we focus on the type of targeted exercise training, the determinants of individual variation, including biological sex and genotypic factors, and the mechanisms by which exercise exerts its influence on the brain. We argue that a better understanding of these factors will allow for evidence-based, personalised, tailored exercise recommendations that go beyond the one-size-fits-all approach to successfully combat dementia.
策略延缓痴呆发病和进展的社会价值怎么强调都不为过。身体活动——非结构化和结构化的身体活动——是促进大脑健康的一种很有前景且具有成本效益的策略。然而，其效果存在很大差异。因此，为了提高其作为健康认知老化的“药物”的实用性，必须确定针对特定运动训练对大脑健康的积极影响的关键调节因素和中介因素。在这篇评论中，我们重点关注有针对性的运动训练的类型、个体差异的决定因素，包括生物性别和基因型因素，以及运动对大脑产生影响的机制。我们认为，更好地了解这些因素将有助于根据证据提供个性化、量身定制的运动建议，超越一刀切的方法，成功对抗痴呆症。
