a Department of Physical Therapy, Aging, Mobility, and Cognitive Neuroscience Laboratory, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
b Djavad Mowafaghian Centre for Brain Health, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Appl Physiol Nutr Metab. 2018 Nov;43(11):1105-1112. doi: 10.1139/apnm-2018-0260. Epub 2018 Oct 11.
Physical activity is a promising strategy for dementia prevention and disease modification. Here, we provide a narrative review of the current evidence from epidemiological and intervention studies on the role of physical activity and exercise in promoting cognitive health in older adults both without and with cognitive impairment. We highlight some of the potential underlying mechanisms and discuss biological sex as a potential moderating factor. We conclude with limitations and future directions for this rapidly expanding line of research.
身体活动是预防痴呆症和改变疾病进程的一种很有前景的策略。在这里，我们对来自流行病学和干预研究的现有证据进行了叙述性综述，这些研究探讨了身体活动和锻炼在促进认知健康方面对认知正常和认知障碍老年人的作用。我们强调了一些潜在的潜在机制，并讨论了生物学性别作为潜在的调节因素。最后，我们对这一快速发展的研究领域的局限性和未来方向进行了总结。
