Vankelecom H, Carmeliet P, Van Damme J, Billiau A, Denef C
Laboratory of Immunobiology, Rega Institute, University of Leuven, School of Medicine, Belgium.
Neuroendocrinology. 1989 Jan;49(1):102-6. doi: 10.1159/000125097.
Reaggregate cell cultures of mouse or rat anterior pituitary were found to produce interleukin-6 (IL-6), a cytokine known for its multiple actions in the immune system. Studies on aggregates prepared from differentially enriched pituitary cell populations revealed the presence of folliculo-stellate (FS) cells to be essential for IL-6 production. Aggregates that contained only hormone-secreting, but no FS cells, failed to produce IL-6. Furthermore, the yield of IL-6 increased with increasing proportions of FS cells present in the aggregates. It is suggested that IL-6 participates in the local regulation of the secretory function of the hypophysis and may constitute a link between events in the immune system and those in the endocrine system.
已发现，小鼠或大鼠垂体前叶的重聚集细胞培养物可产生白细胞介素-6（IL-6），这是一种在免疫系统中具有多种作用而闻名的细胞因子。对由不同富集的垂体细胞群体制备的聚集体进行的研究表明，滤泡星状（FS）细胞的存在对于IL-6的产生至关重要。仅含有激素分泌细胞而没有FS细胞的聚集体无法产生IL-6。此外，聚集体中IL-6的产量随着FS细胞比例的增加而增加。有人提出，IL-6参与垂体分泌功能的局部调节，并且可能构成免疫系统和内分泌系统事件之间的联系。
