Wu Ping, Zhou Yu-Mei, Zeng Fang, Li Zheng-Jie, Luo Lu, Li Yong-Xin, Fan Wei, Qiu Li-Hua, Qin Wei, Chen Lin, Bai Lin, Nie Juan, Zhang San, Xiong Yan, Bai Yu, Yin Can-Xin, Liang Fan-Rong
Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
China Academy of Chinese Medical Sciences, World Federation of Acupuncture-Moxibustion Societies, Beijing, China.
Neural Regen Res. 2016 Sep;11(9):1424-1430. doi: 10.4103/1673-5374.191215.
Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clinical rating scales of the Fugl-Meyer Motor Assessment ( = -0.609, = 0.047) and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale ( = -0.737, = 0.010). Our findings can objectively identify the functional abnormality in some brain regions of ischemic stroke patients.
我们之前的研究采用局部一致性分析，发现缺血性中风患者某些脑区的活动发生了显著变化。在当前研究中，我们通过对11例缺血性中风患者和15名健康参与者进行结构磁共振成像扫描，并使用基于体素的形态学测量方法分析数据，来检查这些脑区的结构变化。与健康参与者相比，患者在左侧枕下回和右侧前部白质束表现出更高的灰质密度。相反，缺血性中风患者右侧小脑、左侧中央前回、右侧额中回和左侧颞中回的灰质密度较低。额中回灰质密度的变化与Fugl-Meyer运动评估临床评分量表呈负相关（r = -0.609，P = 0.047），左侧颞中回与神经功能缺损量表临床评分量表呈负相关（r = -0.737，P = 0.010）。我们的研究结果能够客观地识别缺血性中风患者某些脑区的功能异常。
