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2
Acquired Immunoglobulin G deficiency in stroke patients and experimental brain ischemia.中风患者及实验性脑缺血中的获得性免疫球蛋白G缺乏症
Exp Neurol. 2015 Sep;271:46-52. doi: 10.1016/j.expneurol.2015.04.021. Epub 2015 May 7.
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B-lymphocyte-mediated delayed cognitive impairment following stroke.中风后B淋巴细胞介导的迟发性认知障碍。
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Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size.中风患者会产生针对 N-甲基-D-天冬氨酸受体亚基 1 组成部分的抗体，其数量与病变大小成正比。
Stroke. 2013 Aug;44(8):2212-9. doi: 10.1161/STROKEAHA.113.001235. Epub 2013 May 30.
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Myelin basic protein autoantibodies, white matter disease and stroke outcome.髓鞘碱性蛋白自身抗体、脑白质病变与卒中转归。
J Neuroimmunol. 2012 Nov 15;252(1-2):106-12. doi: 10.1016/j.jneuroim.2012.08.006. Epub 2012 Aug 29.
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Autoimmune responses to the brain after stroke are associated with worse outcome.中风后对大脑的自身免疫反应与预后不良有关。
Stroke. 2011 Oct;42(10):2763-9. doi: 10.1161/STROKEAHA.111.619593. Epub 2011 Jul 28.
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Sensitization to brain antigens after stroke is augmented by lipopolysaccharide.中风后对脑抗原的致敏作用会因脂多糖而增强。
J Cereb Blood Flow Metab. 2005 Dec;25(12):1634-44. doi: 10.1038/sj.jcbfm.9600160.
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Dementia after stroke: the Framingham Study.中风后痴呆：弗雷明汉姆研究。
Stroke. 2004 Jun;35(6):1264-8. doi: 10.1161/01.STR.0000127810.92616.78. Epub 2004 Apr 29.
9
Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke.检测N-甲基-D-天冬氨酸神经受体自身抗体的血液检测，用于评估短暂性脑缺血发作和中风患者。
Clin Chem. 2003 Oct;49(10):1752-62. doi: 10.1373/49.10.1752.
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Incidence of dementia after ischemic stroke: results of a longitudinal study.缺血性中风后痴呆的发病率：一项纵向研究的结果
Stroke. 2002 Sep;33(9):2254-60. doi: 10.1161/01.str.0000028235.91778.95.

抗髓鞘碱性蛋白抗体与中风后的认知功能衰退有关。

Antibodies to myelin basic protein are associated with cognitive decline after stroke.

作者信息

Becker Kyra J, Tanzi Patricia, Zierath Dannielle, Buckwalter Marion S

机构信息

Department of Neurology, University of Washington School of Medicine, United States.

Department of Neurology, University of Washington School of Medicine, United States.

出版信息

J Neuroimmunol. 2016 Jun 15;295-296:9-11. doi: 10.1016/j.jneuroim.2016.04.001. Epub 2016 Apr 9.

DOI:10.1016/j.jneuroim.2016.04.001
PMID:27235342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4884610/
Abstract

B lymphocytes cause post-stroke cognitive decline in mice. We therefore evaluated the association between autoantibodies and post-stroke cognitive decline in a prospectively collected human cohort. The mini-mental state exam (MMSE) was administered 30, 90, 180, and 365days after stroke. Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 subjects with initial MMSE≥20 and at least 2 MMSE examinations in the year after stroke, cognitive decline (MMSE decrease ≥2) occurred in 10 (17%) subjects. In multivariate analysis, MBP antibody titers were the only independent predictor of cognitive decline (OR=9.02 [1.18, 68.90]; P=0.03).

摘要

B淋巴细胞会导致小鼠中风后认知功能下降。因此，我们在一个前瞻性收集的人类队列中评估了自身抗体与中风后认知功能下降之间的关联。在中风后30、90、180和365天进行简易精神状态检查（MMSE）。测定了针对髓鞘碱性蛋白（MBP）、蛋白脂蛋白和几种非特异性蛋白的抗体滴度。在58名初始MMSE≥20且在中风后一年内至少进行2次MMSE检查的受试者中，10名（17%）受试者出现了认知功能下降（MMSE降低≥2）。在多变量分析中，MBP抗体滴度是认知功能下降的唯一独立预测因素（OR=9.02 [1.18, 68.90]；P=0.03）。