Maehlen J, Olsson T, Zachau A, Klareskog L, Kristensson K
Division of Cellular and Neuropathology, Karolinska Institutet, Huddinge Hospital, Stockholm, Sweden.
J Neuroimmunol. 1989 Jul;23(2):125-32. doi: 10.1016/0165-5728(89)90031-3.
The effect of unilateral peripheral nerve lesions on the inflammatory response of experimental allergic encephalomyelitis (EAE) in rat central nervous system (CNS) was studied. Immunostaining for major histocompatibility complex (MHC) antigens and T-cell subsets demonstrated that MHC class I expression was markedly enhanced in as well as around axotomized motor neurons and that MHC class II expression was induced on several cells, probably microglial cells, in close proximity to the axotomized motor neurons. There was also a pronounced increase in interleukin 2 receptor-positive lymphocytes as well as T-cells and the T-cell subsets on the injured as compared to the non-injured contralateral side. These effects were present particularly in the initial phase of EAE and persisted for several weeks. The results suggest that neurons may communicate immunoregulatory signals to their microenvironment and that retrograde axonal signals from the distant periphery may alter the immune response locally within the CNS.
研究了单侧周围神经损伤对大鼠中枢神经系统（CNS）实验性自身免疫性脑脊髓炎（EAE）炎症反应的影响。主要组织相容性复合体（MHC）抗原和T细胞亚群的免疫染色显示，MHC I类表达在轴突切断的运动神经元及其周围明显增强，并且在靠近轴突切断的运动神经元的几个细胞（可能是小胶质细胞）上诱导了MHC II类表达。与未受伤的对侧相比，受伤侧白细胞介素2受体阳性淋巴细胞以及T细胞和T细胞亚群也有明显增加。这些效应尤其在EAE的初始阶段出现，并持续数周。结果表明，神经元可能向其微环境传递免疫调节信号，并且来自远处外周的逆行轴突信号可能会改变CNS内局部的免疫反应。
