Takahashi Maiko, Motoyoshi Mitsuru, Inaba Mizuki, Hagiwara Yoshiyuki, Shimizu Noriyoshi
Int J Oral Maxillofac Implants. 2016 Nov/Dec;31(6):1320-1326. doi: 10.11607/jomi.4706.
Ultraviolet (UV)-mediated photofunctionalization technology is intended to enhance the osseointegration capability of titanium implants. There are concerns about orthodontic anchor screws loosening under immediate loading protocols in adolescent orthodontic treatment. The purpose of this in vivo study was to evaluate the effects of photofunctionalization on the intrabony stability of orthodontic titanium anchor screws and bone-anchor screw contact under immediate loading in growing rats.
Custom-made titanium anchor screws (1.4 mm in diameter and 4.0 mm in length) with or without photofunctionalization pretreatment were placed on the proximal epiphysis of the tibial bone in 6-week-old male Sprague-Dawley rats and were loaded immediately after placement. After 2 weeks of loading, the stability of the anchor screws was evaluated using a Periotest device, and the bone-anchor screw contact ratio (BSC) was assessed by a histomorphometric analysis using field-emission scanning electron microscopy.
In the unloaded group, Periotest values (PTVs) were ~25 for UV-untreated screws and 13 for UVtreated screws (P < .01), while in the immediate-loading group, PTVs were 28 for UV-untreated screws and 16 for UV-treated screws (P < .05). Significantly less screw mobility was observed in both UV-treated groups regardless of the loading protocol. The BSC was increased ~1.8 fold for UV-treated screws, compared with UV-untreated screws, regardless of the loading protocol.
Photofunctionalization enhanced the intrabony stability of orthodontic anchor screws under immediate loading in growing rats by increasing bone-anchor screw contact.
紫外线介导的光功能化技术旨在增强钛植入物的骨整合能力。在青少年正畸治疗中,对于即刻加载方案下正畸支抗螺钉松动存在担忧。本体内研究的目的是评估光功能化对生长中大鼠即刻加载下正畸钛支抗螺钉的骨内稳定性及骨与螺钉接触的影响。
将经过或未经过光功能化预处理的定制钛支抗螺钉(直径1.4 mm,长度4.0 mm)植入6周龄雄性Sprague-Dawley大鼠胫骨近端骨骺,植入后即刻加载。加载2周后,使用Periotest装置评估支抗螺钉的稳定性,并通过场发射扫描电子显微镜进行组织形态计量分析来评估骨与螺钉接触率(BSC)。
在未加载组中,未进行紫外线处理的螺钉Periotest值(PTV)约为25,经紫外线处理的螺钉为13(P <.01);而在即刻加载组中,未进行紫外线处理的螺钉PTV为28,经紫外线处理的螺钉为16(P <.05)。无论加载方案如何,在两个经紫外线处理的组中均观察到螺钉移动性明显降低。无论加载方案如何,与未进行紫外线处理的螺钉相比,经紫外线处理的螺钉BSC增加了约1.8倍。
光功能化通过增加骨与螺钉的接触,增强了生长中大鼠即刻加载下正畸支抗螺钉的骨内稳定性。