Research Assistant, Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, Calif; and Resident, Advanced Specialty Education Program in Prosthodontics, Loma Linda University, School of Dentistry, Loma Linda, Calif.
Research Assistant, Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, Calif; and Resident, Periodontics Department, Saint Louis University, Center for Advanced Dental Education, St Louis, Mo.
J Prosthet Dent. 2017 Sep;118(3):357-362. doi: 10.1016/j.prosdent.2016.11.008. Epub 2017 Feb 17.
Despite its clinical benefits, the immediate loading protocol might have a higher risk of implant failure than the regular protocol. Ultraviolet (UV) photofunctionalization is a novel surface enhancement technique for dental implants. However, the effect of photofunctionalization under loading conditions is unclear.
The purpose of this animal study was to evaluate the effect of photofunctionalization on the biomechanical quality and strength of osseointegration under loaded conditions in a rat model.
Untreated and photofunctionalized, acid-etched titanium implants were placed into rat femurs. The implants were immediately loaded with 0.46 N of constant lateral force. The implant positions were evaluated after 2 weeks of healing. The strength of osseointegration was evaluated by measuring the bone-implant interfacial breakdown point during biomechanical push-in testing.
Photofunctionalization induced hydrophilic surfaces on the implants. Osseointegration was successful in 28.6% of untreated implants and 100% of photofunctionalized implants. The strength of osseointegration in successful implants was 2.4 times higher in photofunctionalized implants than in untreated implants. The degree of tilt of untreated implants toward the origin of force was twice that of photofunctionalized implants.
Within the limit of an animal model, photofunctionalization significantly increased the success of osseointegration and prevented implant tilt. Even for the implants that underwent successful osseointegration, the strength of osseointegration was significantly higher for photofunctionalized implants than for untreated implants. Further experiments are warranted to determine the effectiveness of photofunctionalization on immediately loaded dental implants.
尽管即刻负载方案具有临床益处，但与常规方案相比，其种植体失败的风险可能更高。紫外线（UV）光功能化是一种用于牙科植入物的新型表面增强技术。然而，在负载条件下光功能化的效果尚不清楚。
本动物研究的目的是评估光功能化对负载条件下大鼠模型中骨整合的生物力学质量和强度的影响。
将未经处理和光功能化的酸蚀钛植入物放置在大鼠股骨中。将植入物立即加载 0.46N 的恒定侧向力。在 2 周的愈合期后评估植入物位置。通过生物力学推入测试测量骨-植入物界面的破坏点来评估骨整合的强度。
光功能化在植入物上诱导出亲水表面。未经处理的植入物中有 28.6%成功实现了骨整合，而光功能化的植入物则达到了 100%。在成功植入的情况下，光功能化植入物的骨整合强度比未经处理的植入物高 2.4 倍。未经处理的植入物向力的起源倾斜的程度是光功能化植入物的两倍。
在动物模型的限制范围内，光功能化显著提高了骨整合的成功率并防止了植入物倾斜。即使对于成功实现骨整合的植入物，光功能化植入物的骨整合强度也明显高于未经处理的植入物。需要进一步的实验来确定光功能化对即刻负载牙科植入物的有效性。
