Torubarova N A, Kurmashov V I, Dolotova L V, Susuleva N A, Il'iashenko V V
Pediatriia. 1989(2):38-42.
Antilymphocytic monoclonal antibodies of HKO and OKT series were used to study surface antigens of peripheral blood and lymph node lymphocytes in 13 untreated patients with Hodgkin's disease. The purpose of the study was to identify the pathogenetic mechanism underlying the development of immunodeficiency in the early disease stages. The data obtained have demonstrated that the deficiency of T lymphocytes in the peripheral blood was connected with that of mature T cells in the lymph nodes revealed with the use of differential antigens complex. Deficiency of immunologically differentiated T lymphocytes in the lymph nodes combined with high counts of the cells whose membranes carry Ia-like antigen point to the immunologically unfavourable course of the disease.
使用HKO和OKT系列抗淋巴细胞单克隆抗体，对13例未经治疗的霍奇金病患者外周血和淋巴结淋巴细胞的表面抗原进行了研究。本研究的目的是确定疾病早期免疫缺陷发生发展的发病机制。所获得的数据表明，外周血中T淋巴细胞的缺乏与使用差异抗原复合物所揭示的淋巴结中成熟T细胞的缺乏有关。淋巴结中免疫分化T淋巴细胞的缺乏，加上细胞膜携带Ia样抗原的细胞数量增多，表明疾病的免疫进程不利。
