饮食能量限制对自身免疫易感性小鼠中Ly-1+ B淋巴细胞数量及比例的影响。
Influence of dietary energy restriction on the numbers and proportions of Ly-1+ B lymphocytes in autoimmunity-prone mice.
作者信息
Ogura M, Ogura H, Ikehara S, Good R A
机构信息
All Children's Hospital, University of South Florida, Saint Petersburg 33701.
出版信息
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4225-9. doi: 10.1073/pnas.86.11.4225.
Chronic energy-intake restriction (CEIR) has been shown to increase life-span, delay diseases expression, and inhibit immunological perturbations in all strains of autoimmunity-prone mice studied, including NZB, (NZB x NZW)F1, MRL/Mp-lpr/lpr, BXSB, and kd/kd mice. In (NZB x NZB)F1 mice, increased percentages and increased absolute numbers of Ly-1+ B lymphocytes in spleen, mesenteric lymph nodes, thymus, and bone marrow as revealed by two-color immunofluorescence analysis were greatly reduced by CEIR with a diet high in carbohydrate and low in fat. This influence on a possibly crucial lymphocyte subpopulation was associated with delayed onset of disease and with greatly prolonged life-span. In the present investigation, the percentages and absolute number of Ly-1+ B lymphocytes in the spleen, peritoneal exudate, and peripheral blood were found to be increased in each autoimmunity-prone strain studied. CEIR decreased the absolute and relative numbers of the Ly-1+ B lymphocytes in mice of each of the autoimmunity-prone strains and returned the number and proportions of Ly-1+ B cells close to levels present in the same locations in genetically long-lived C57BL/6, DBA/2, or BALB/c mice fed a standard commercial diet ad libitum.
长期能量摄入限制（CEIR）已被证明可延长寿命、延缓疾病表现，并抑制所研究的所有自身免疫易感小鼠品系中的免疫紊乱，这些品系包括新西兰黑鼠（NZB）、（新西兰黑鼠×新西兰白鼠）F1、MRL/Mp-lpr/lpr、BXSB和kd/kd小鼠。在（新西兰黑鼠×新西兰黑鼠）F1小鼠中，通过双色免疫荧光分析发现，脾脏、肠系膜淋巴结、胸腺和骨髓中Ly-1+B淋巴细胞的百分比增加且绝对数量增多，而高碳水化合物、低脂肪饮食的CEIR可使其大幅降低。这种对可能关键的淋巴细胞亚群的影响与疾病发病延迟和寿命大幅延长相关。在本研究中，在所研究的每个自身免疫易感品系中，脾脏、腹腔渗出液和外周血中Ly-1+B淋巴细胞的百分比和绝对数量均增加。CEIR降低了每个自身免疫易感品系小鼠中Ly-1+B淋巴细胞的绝对数量和相对数量，并使Ly-1+B细胞的数量和比例恢复到随意喂食标准商业饮食的遗传长寿C57BL/6、DBA/2或BALB/c小鼠相同部位的水平。
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