Miraca Life Sciences, Irving, TX, USA.
Oregon Health & Science University, Portland, OR, USA.
Aliment Pharmacol Ther. 2017 Jan;45(2):283-290. doi: 10.1111/apt.13854. Epub 2016 Nov 9.
Environmental risk factors associated with ethnicity may contribute to the occurrence of Barrett's metaplasia.
To investigate the interaction between ethnicity and Helicobacter pylori infection in the occurrence of Barrett's metaplasia among patients undergoing oesophago-gastro-duodenoscopy.
The Miraca Life Sciences Database is an electronic repository of histopathological patient records. A case-control study evaluated the influence of age, gender, ethnicity and histological diagnosis of H. pylori on the occurrence of Barrett's metaplasia.
The total study population comprised 596 479 subjects, of whom 76 475 harboured a diagnosis of Barrett's metaplasia. Male sex, age and H. pylori infection in declining order exerted the strongest influence on the occurrence of BM. In comparison with the population comprising Caucasians and African Americans, Barrett's metaplasia was less common among subjects of African (OR = 0.09, 95% CI = 0.01-0.43), Middle Eastern (0.26, 0.20-0.34), East Asian (0.35, 0.31-0.40), Indian (0.39, 0.32-0.47), Hispanic (0.62, 0.59-0.64) or Jewish descent (0.50, 0.45-0.54), but more common among subjects of Northern European descent (1.14, 1.03-1.26). With the exception of Jews and Northern Europeans, all other ethnic subgroups were characterised by a higher prevalence of H. pylori than the comparison group. A low prevalence of H. pylori was significantly associated with a high prevalence of Barrett's metaplasia (R = 0.82, P < 0.001), as well as dysplasia or oesophageal adenocarcinoma (R = 0.81, P < 0.001).
Our analysis reveals an inverse relationship between the prevalence of Barrett's metaplasia and H. pylori gastritis among different ethnic groups within the United States.
与族裔相关的环境风险因素可能导致 Barrett 化生的发生。
调查在接受食管胃十二指肠镜检查的患者中，种族与幽门螺杆菌感染之间的相互作用与 Barrett 化生的发生。
Miraca 生命科学数据库是一个组织病理学患者记录的电子存储库。一项病例对照研究评估了年龄、性别、种族和幽门螺杆菌的组织学诊断对 Barrett 化生发生的影响。
总研究人群包括 596479 例患者，其中 76475 例诊断为 Barrett 化生。按男性、年龄和幽门螺杆菌感染的顺序，它们对 BM 的发生影响最大。与白种人和非裔美国人组成的人群相比，非洲裔（比值比=0.09，95%置信区间=0.01-0.43）、中东裔（0.26，0.20-0.34）、东亚裔（0.35，0.31-0.40）、印度裔（0.39，0.32-0.47）、西班牙裔（0.62，0.59-0.64）或犹太裔（0.50，0.45-0.54）人群的 Barrett 化生发生率较低，但北欧裔（1.14，1.03-1.26）人群的发生率较高。除了犹太人之外，所有其他种族亚组的幽门螺杆菌流行率均高于对照组。幽门螺杆菌低流行率与 Barrett 化生（R=0.82，P<0.001）以及异型增生或食管腺癌（R=0.81，P<0.001）的高流行率显著相关。
我们的分析揭示了美国不同族裔人群中 Barrett 化生的流行率与幽门螺杆菌胃炎之间存在反比关系。
