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单形性亲上皮性肠道T细胞淋巴瘤中的多形红斑样皮肤病变:一例罕见病例报告

Erythema multiforme-like cutaneous lesions in monomorphic epitheliotropic intestinal T-cell lymphoma: a rare case report.

作者信息

Aiempanakit Kumpol, Amatawet Chitiarpa, Chiratikarnwong Kanokphorn, Auepemkiate Sauvarat, Kayasut Kanita, Suwiwat Supaporn, Apinantriyo Benjawan

机构信息

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

出版信息

J Cutan Pathol. 2017 Feb;44(2):183-188. doi: 10.1111/cup.12864. Epub 2016 Dec 15.

Abstract

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), also known as Type II enteropathy-associated T-cell lymphoma (EATL), is an aggressive peripheral T-cell lymphoma. EATL generally presents in adults with gastrointestinal symptoms. Skin involvement is very rare, found only in approximately five percent of patients. The authors report a 67-year-old Asian male who presented with chronic diarrhea and developed erythema multiforme-like cutaneous lesions. A skin biopsy revealed extensive pagetoid spread of atypical lymphocytes in the epidermis. The results of an immunohistochemistry test led to a diagnosis of MEITL. This report points to the need for dermatologists and dermatopathologists to consider a possible diagnosis of MEITL when encountering similar cases.

摘要

单形性嗜上皮性肠道T细胞淋巴瘤(MEITL),也称为II型肠病相关T细胞淋巴瘤(EATL),是一种侵袭性外周T细胞淋巴瘤。EATL通常在成人中出现,伴有胃肠道症状。皮肤受累非常罕见,仅在约5%的患者中发现。作者报告了一名67岁的亚洲男性,他出现慢性腹泻并发展为多形红斑样皮肤病变。皮肤活检显示表皮中非典型淋巴细胞广泛呈派杰样扩散。免疫组织化学检测结果导致诊断为MEITL。本报告指出,皮肤科医生和皮肤病理学家在遇到类似病例时需要考虑MEITL的可能诊断。

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