Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA
Ann Clin Lab Sci. 2020 Nov;50(6):806-812.
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare primary and highly aggressive intestinal T-cell lymphoma derived from intraepithelial lymphocytes. MEITL is previously designated as type II enteropathy-associated T cell lymphoma (EATL). Unlike to classic form of EATL, MEITL is not associated with celiac disease. The diagnosis of MEITL is very challenging and the clinical outcome of patients with MEITL is very poor. Herein we describe a series of four patients diagnosed with MEITL identified upon a 10-year institutional retrospective review. Histopathologic examination of these cases revealed monotonous population of medium sized cells infiltrating intestinal mucosa, positive for CD3, CD8 and CD56 in all four cases. Two patients had the combination chemotherapy; however, the average survival time was only 7.5 months for these two patients after diagnosis. The aim of the present case series is to highlight the pathology, diagnosis and clinical course of the patients with MEITL based on the current literature.
单一表型上皮样肠道 T 细胞淋巴瘤（MEITL）是一种罕见的原发性、高度侵袭性的肠道 T 细胞淋巴瘤，来源于上皮内淋巴细胞。MEITL 以前被指定为 II 型肠病相关 T 细胞淋巴瘤（EATL）。与经典型 EATL 不同，MEITL 与乳糜泻无关。MEITL 的诊断极具挑战性，且 MEITL 患者的临床预后非常差。在此，我们描述了在机构回顾性研究的 10 年期间诊断的 4 例 MEITL 患者。对这些病例的组织病理学检查显示，中大型细胞弥漫性浸润肠黏膜，所有 4 例均为 CD3、CD8 和 CD56 阳性。2 例患者接受了联合化疗，但这 2 例患者在诊断后平均生存时间仅为 7.5 个月。本病例系列的目的是基于现有文献，强调 MEITL 患者的病理学、诊断和临床过程。
