Zhurkin A T, Dubinina E E, Koriagin V N
Ter Arkh. 1989;61(2):58-60.
The paper is concerned with the measurement of the relative and absolute counts of lymphocytes, T and B lymphocytes (106 patients) and superoxide dismutase (SOD) activity of red blood cells (237 patients) in acute and chronic viral hepatitis (VH). In addition, a study was made of SOD activity of red blood cells in guinea-pigs immunized with bovine serum albumin (BSA). It is shown that SOD activation in red blood cells related to the enzyme induction with superoxide anionic radical was seen both in patients with acute and chronic VH and in guinea-pigs immunized with BSA. The patients with acute and chronic VH demonstrated the reduction of the absolute count of T lymphocytes and the increase of the B lymphocyte count in the peripheral blood together with SOD activation in red blood cells, more remarkable in acute than in chronic VH. The immunological response in VH patients manifested since days 14-20 from the disease onset or its exacerbation which was evidenced by changes in the cooperative interaction of cellular immunity and SOD activity.
本文关注急性和慢性病毒性肝炎（VH）患者淋巴细胞、T淋巴细胞和B淋巴细胞的相对及绝对计数（106例患者）以及红细胞超氧化物歧化酶（SOD）活性（237例患者）的测定。此外，还对用牛血清白蛋白（BSA）免疫的豚鼠红细胞SOD活性进行了研究。结果表明，急性和慢性VH患者以及用BSA免疫的豚鼠红细胞中均出现了与超氧阴离子自由基诱导酶相关的SOD激活。急性和慢性VH患者外周血中T淋巴细胞绝对计数减少，B淋巴细胞计数增加，同时红细胞SOD激活，急性VH比慢性VH更明显。VH患者的免疫反应在疾病发作或加重后14 - 20天出现，这通过细胞免疫协同相互作用和SOD活性的变化得到证实。
