Matveĭkov G P, Kaliia E S, Levin V I, San'ko N M
Ter Arkh. 1994;66(4):57-61.
General activity of superoxide dismutase (SOD) and its isoenzymic spectrum in lymphocytes and neutrophils were studied in the peripheral blood from 63 SLP and 85 RA patients. A significant decline in SOD activity and qualitative shifts in SOD isoenzymic spectrum were found in both cell groups. The differences were specific for lymphocytes and neutrophils. SOD isoenzymic aberrations proved significant in minimal activity of SLP and RA and go in the same direction in both the diseases. General SOD activity and its isoenzymic composition can serve sensitive indications of immunocompetent cell function both in SLP and RA and of the need in antioxidants inclusion into combined treatment of both the diseases.
对63例干燥综合征（SLP）患者和85例类风湿关节炎（RA）患者外周血淋巴细胞和中性粒细胞中的超氧化物歧化酶（SOD）总体活性及其同工酶谱进行了研究。在这两组细胞中均发现SOD活性显著下降以及SOD同工酶谱的定性变化。这些差异在淋巴细胞和中性粒细胞中具有特异性。SOD同工酶异常在SLP和RA的最低活动度中被证明具有显著性，且在两种疾病中变化方向相同。SOD总体活性及其同工酶组成可作为SLP和RA中免疫活性细胞功能的敏感指标，以及这两种疾病联合治疗中纳入抗氧化剂必要性的敏感指标。
