组蛋白乙酰化的各种代谢来源。
The Various Metabolic Sources of Histone Acetylation.
机构信息
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA.
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
出版信息
Trends Endocrinol Metab. 2017 Feb;28(2):85-87. doi: 10.1016/j.tem.2016.11.001. Epub 2016 Nov 16.
Glucose-derived acetyl-CoA levels directly impact histone acetylation, linking the energetic status of the cell to its epigenome. Two recent reports showed that other carbon sources can contribute to the acetyl-CoA pool used for histone acetylation, highlighting the metabolic plasticity that allows cells to respond to nutrient availability.
葡萄糖衍生的乙酰辅酶 A 水平直接影响组蛋白乙酰化，将细胞的能量状态与其表观基因组联系起来。最近的两项研究报告表明，其他碳源可以为用于组蛋白乙酰化的乙酰辅酶 A 池做出贡献，这突出了允许细胞响应营养物质可用性的代谢灵活性。
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