Bushnell D L, Gupta S, Mlcoch A G, Barnes W E
Nuclear Medicine Service, Hines Veterans Administration Hospital, IL 60141.
Arch Neurol. 1989 Jun;46(6):665-9. doi: 10.1001/archneur.1989.00520420085027.
Fourteen patients (10 with left-sided and 4 with right-sided cerebral infarction) were prospectively studied with single-photon emission computed tomography (SPECT) using N-isopropyl-p-(I 123) iodoamphetamine (IMP, SPECTamine) to determine its usefulness in predicting neurologic/language recovery after cerebral infarction. All neuro-SPECT imaging was performed within 30 days after infarction. Detailed assessment of neurologic and/or language recovery (after 3 months) was carried out prospectively in each patient. Patients with smaller volume IMP defects in the region of infarction demonstrated significantly better neurologic and language recovery than patients with large IMP defects. Analysis of the IMP "redistribution" phenomenon failed to demonstrate definitively a relationship with clinical recovery. It was concluded that the volume of the IMP defect can aid in predicting recovery potential after cerebral infarction.
对14例患者（10例左侧脑梗死和4例右侧脑梗死）进行了前瞻性研究，采用单光子发射计算机断层扫描（SPECT），使用N-异丙基-p-（I 123）碘安非他明（IMP，SPECTamine）来确定其在预测脑梗死神经功能/语言恢复方面的有效性。所有神经SPECT成像均在梗死发生后30天内进行。对每位患者进行了前瞻性的详细神经功能和/或语言恢复评估（3个月后）。梗死区域IMP缺损体积较小的患者，其神经功能和语言恢复明显优于IMP缺损较大的患者。对IMP“再分布”现象的分析未能明确证明其与临床恢复之间的关系。得出的结论是，IMP缺损的体积有助于预测脑梗死的恢复潜力。
