Gupta S, Bushnell D L, Mlcoch A, Eastman G, Barnes W E, Fisher S G
Neurology Service, Veterans Affairs Hines Hospital, IL 60141.
Stroke. 1991 Dec;22(12):1512-8. doi: 10.1161/01.str.22.12.1512.
The purpose of this study was to determine utility of late N-isopropyl-p-(iodine-123)-iodoamphetamine distribution in predicting neurological and language outcome.
We prospectively studied 29 patients with unilateral hemispheric ischemic cerebral infarction using the neuroimaging method of single-photon emission computed tomography and the above tracer. Four different imaging measures reflecting late tracer distribution or redistribution and three measures indicative of the patients' overall neurological or language outcome at 3 months were used in the data analysis. All patients had neuroimaging within 30 days of infarction, and 14 patients were imaged within 10 days of infarction. Data analysis was performed for all patients combined and then separately on the groups imaged within 10 days of and more than 10 days after infarction.
The volume of the late image defect significantly correlated with one measure of neurological outcome in the whole group and in those imaged more than 10 days after cerebral infarction. However, these results are difficult to explain based on the present understanding of the physiology of late N-isopropyl-p-(iodine-123)-iodoamphetamine distribution.
We feel that the pattern of late N-isopropyl-p-(iodine-123)-iodoamphetamine distribution is probably not useful as an independent predictor of neurological and language outcome.
本研究旨在确定晚期 N-异丙基-p-(碘-123)-碘安非他明分布在预测神经和语言预后方面的效用。
我们使用单光子发射计算机断层扫描的神经成像方法及上述示踪剂，对29例单侧半球缺血性脑梗死患者进行了前瞻性研究。数据分析中使用了四种反映晚期示踪剂分布或再分布的不同成像测量方法，以及三种指示患者3个月时总体神经或语言预后的测量方法。所有患者在梗死30天内进行了神经成像，14例患者在梗死10天内进行了成像。对所有患者进行综合数据分析，然后分别对梗死10天内成像的组和梗死10天后成像的组进行分析。
晚期图像缺损体积与整个组以及脑梗死后10天以上成像组的一项神经预后测量指标显著相关。然而，基于目前对晚期N-异丙基-p-(碘-123)-碘安非他明分布生理学的理解，这些结果难以解释。
我们认为，晚期N-异丙基-p-(碘-123)-碘安非他明的分布模式可能无法作为神经和语言预后的独立预测指标。
