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Keloid fibroblasts in culture: abnormal growth behaviour and altered response to the epidermal growth factor.

作者信息

Harper R A

机构信息

Connective Tissue Research Institute, University City Science Center, Philadelphia, Pennsylvania 19104.

出版信息

Cell Biol Int Rep. 1989 Apr;13(4):325-35. doi: 10.1016/0309-1651(89)90159-8.

DOI:10.1016/0309-1651(89)90159-8
PMID:2786458
Abstract

Keloid fibroblasts were propagated in culture and their proliferative behaviour and response to the Epidermal Growth Factor (EGF) were studied. Keloid fibroblasts grew at a rate which was approximately one-half that of normal age, sex and race matched control fibroblasts. Keloid fibroblasts were stimulated to grow in the presence of EGF (10 ng/ml), but to a lesser degree than the normal control fibroblasts. Scatchard analysis of the binding data obtained using 125I-labeled EGF revealed no difference in binding affinity or receptor numbers between keloid and normal fibroblasts.

摘要

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