Peña Javier, Ibarretxe-Bilbao Naroa, Sánchez Pedro, Iriarte Maria B, Elizagarate Edorta, Garay Maria A, Gutiérrez Miguel, Iribarren Aránzazu, Ojeda Natalia
Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto , Bilbao, Spain.
Refractory Psychosis Unit, Hospital Psiquiátrico de Alava, C/Alava, Vitoria, Spain; Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, University of the Basque Country, Vizcaya, Spain.
NPJ Schizophr. 2016 Nov 9;2:16037. doi: 10.1038/npjschz.2016.37. eCollection 2016.
This study examined the efficacy of an integrative cognitive remediation program (REHACOP) in improving cognition and functional outcome in patients with schizophrenia. The program combines cognitive remediation, social cognitive intervention, and functional skills training. Few studies have attempted this approach. One hundred and eleven patients diagnosed with schizophrenia were randomly assigned to either the cognitive remediation group (REHACOP) or an active control group (occupational activities) for 4 months (three sessions per week, 90 min). Primary outcomes were change on general neurocognitive performance and social cognition, including theory of mind (ToM), emotion perception (EP), attributional style, and social perception (SP). Secondary outcomes included changes on clinical symptoms (Positive and Negative Syndrome Scale) and functional outcome (UCSD Performance-Based Skills Assessment and the Global Assessment of Functioning). The trial was registered with clinicaltrials.gov (NCT02796417). No baseline group differences were found. Significant differences were found in the mean change between the REHACOP group and control group in neurocognition ([Formula: see text]), SP ([Formula: see text]), ToM ([Formula: see text]), EP ([Formula: see text]), negative symptoms ([Formula: see text]), emotional distress ([Formula: see text]), Global Assessment of Functioning ([Formula: see text]), and UCSD Performance-Based Skills Assessment ([Formula: see text]). The combination of cognitive remediation, social cognitive intervention, and functional skills training demonstrated statistically significant and clinically meaningful changes in neurocognition, social cognition, negative, and functional disability.
本研究考察了综合认知康复计划（REHACOP）对改善精神分裂症患者认知及功能结局的疗效。该计划结合了认知康复、社会认知干预和功能技能训练。很少有研究尝试这种方法。111名被诊断为精神分裂症的患者被随机分配到认知康复组（REHACOP）或积极对照组（职业活动组），为期4个月（每周三次，每次90分钟）。主要结局指标为一般神经认知表现和社会认知的变化，包括心理理论（ToM）、情绪感知（EP）、归因风格和社会感知（SP）。次要结局指标包括临床症状（阳性和阴性症状量表）和功能结局（基于UCSD表现的技能评估和功能总体评估）的变化。该试验已在clinicaltrials.gov上注册（NCT02796417）。未发现基线组间差异。REHACOP组与对照组在神经认知（[公式：见原文]）、SP（[公式：见原文]）、ToM（[公式：见原文]）、EP（[公式：见原文]）、阴性症状（[公式：见原文]）、情绪困扰（[公式：见原文]）、功能总体评估（[公式：见原文]）和基于UCSD表现的技能评估（[公式：见原文]）的平均变化上存在显著差异。认知康复、社会认知干预和功能技能训练的组合在神经认知、社会认知、阴性症状和功能残疾方面显示出具有统计学意义和临床意义的变化。
