Senger Donald R, Cao Shugeng
Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Department of Pharmaceutical Sciences, Daniel K Inouye College of Pharmacy, University of Hawaii at Hilo, 200 W. Kawili Street, Hilo, HI 96720, USA.
J Nat Sci. 2016;2(11).
Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders. Recently, we reported 4-ethyl catechol and 4-vinyl catechol as Nrf2 co-factors that can induce Nrf2 as potently as sulforaphane and curcumin. These new Nrf2 co-factors were identified in hot aqueous extract of an herbal medicine , and fermented Noni () juice, which are used traditionally for diabetic wound healing.
Nrf2防御是一种非常重要的细胞机制，用于控制与伤口愈合相关的氧化应激。Nrf2可以诱导许多细胞保护基因，包括HO-1、NQO1和G6PD。在许多已被报道为Nrf2激活剂的天然产物中，萝卜硫素和姜黄素的研究比其他任何物质都更广泛，并且两者都正在进行针对非癌性疾病的临床试验。最近，我们报道了4-乙基儿茶酚和4-乙烯基儿茶酚作为Nrf2辅助因子，可以像萝卜硫素和姜黄素一样有效地诱导Nrf2。这些新的Nrf2辅助因子是在一种草药的热水提取物和发酵诺丽果汁中鉴定出来的，它们传统上用于糖尿病伤口愈合。
