来自光滑鲜卑花的两种新单萜类化合物。
Two new monoterpenes from Sibiraea laevigata.
作者信息
Deng Yu, Zhao Jian-Qiang, Mei Li-Juan, Tao Yan-Duo
机构信息
a Animal Disease and Veterinary Pharmaceutical Institute, Chongqing Academy of Animal Sciences , Rongchang 402460 , China.
b Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province , Northwest Institute of Plateau Biology, Chinese Academy of Sciences , Xining 810008 , China.
出版信息
J Asian Nat Prod Res. 2017 Sep;19(9):877-883. doi: 10.1080/10286020.2016.1258064. Epub 2016 Nov 21.
Two new monoterpenes, 3-(2-oxo-4-methyl-3-pentenyl)furan-5H-2-one (1) and 3-[(2E)-4-hydroxyl-4-methyl-2-pentenyl)]furan-5H-2-one (2), along with eight known compounds (3-10), were isolated from the stalks and infructescence of Sibiraea laevigata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. In addition, all of these isolates were evaluated for their cytotoxic and antioxidant activities. The results showed that compounds 5-7 displayed cytotoxicity with IC values ranging from 34.8 to 43.2 μg ml against tumor cell lines. Furthermore, 5 and 9 showed antioxidant activities.
从光滑鲜卑花的茎和果序中分离出两种新的单萜类化合物，3-(2-氧代-4-甲基-3-戊烯基)呋喃-5H-2-酮(1)和3-[(2E)-4-羟基-4-甲基-2-戊烯基)]呋喃-5H-2-酮(2)，以及8种已知化合物(3-10)。通过包括广泛的一维和二维核磁共振技术在内的光谱方法阐明了它们的结构。此外，对所有这些分离物的细胞毒性和抗氧化活性进行了评估。结果表明，化合物5-7对肿瘤细胞系表现出细胞毒性，IC值范围为34.8至43.2μg/ml。此外，5和9表现出抗氧化活性。
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