来自深山糙苏根部的两种新苯丙素苷。

Two new phenylpropanoid glycosides from the roots of Aruncus sylvester.

作者信息

Que Meng, Su Yan-Fang, Yan Shi-Lun, Zhou Ya-Hui, Gao Xiu-Mei

机构信息

a Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University , Tianjin , 300072 , China.

出版信息

J Asian Nat Prod Res. 2014;16(2):158-62. doi: 10.1080/10286020.2013.841676. Epub 2013 Oct 23.

DOI:10.1080/10286020.2013.841676

PMID:24147759

Abstract

Two new phenylpropanoid glycosides, 1,3,4-tri-O-(E)-caffeoyl-β-d-glucopyranoside (1) and 1,4-di-O-(E)-caffeoyl-β-d-glucopyranoside (2), along with four known phenylpropanoid glycosides (3-6), were isolated from the roots of Aruncus sylvester. The structures of 1 and 2 were elucidated using various spectroscopic methods. Compounds 1 and 2 displayed significant scavenging activity of 2,2-diphenyl-1-picrylhydrazyl free radicals with IC50 values of 110 and 258 μM (ascorbic acid: IC50 = 574 μM).

摘要

从华北地榆的根部分离得到两种新的苯丙素苷，1,3,4-三-O-(E)-咖啡酰基-β-D-吡喃葡萄糖苷（1）和1,4-二-O-(E)-咖啡酰基-β-D-吡喃葡萄糖苷（2），以及四种已知的苯丙素苷（3-6）。通过各种光谱方法阐明了1和2的结构。化合物1和2对2,2-二苯基-1-苦基肼自由基具有显著的清除活性，IC50值分别为110和258 μM（抗坏血酸：IC50 = 574 μM）。