Pietrobelli Angelo, Agosti Massimo, Zuccotti Gianvincenzo
Pediatric Unit, Università degli Studi di Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy.
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Int J Environ Res Public Health. 2016 Nov 17;13(11):1151. doi: 10.3390/ijerph13111151.
Growth and development are key characteristics of childhood and sensitive markers of health and adequate nutrition. The first 1000 days of life-conception through 24 months of age-represent a fundamental period for development and thus the prevention of childhood obesity and its adverse consequences is mandatory. There are many growth drivers during this complex phase of life, such as nutrition, genetic and epigenetic factors, and hormonal regulation. The challenge thus involves maximizing the potential for normal growth without increasing the risk of associated disorders. The Mediterranean Nutrition Group (MeNu Group), a group of researchers of the Mediterranean Region, in this Special Issue titled "Prevent Obesity in the First 1000 Days", presented results that advanced the science of obesity risk factors in early life, coming both from animal model studies and studies in humans. In the future, early-life intervention designs for the prevention of pediatric obesity will need to look at different strategies, and the MeNu Group is available for guidance regarding an appropriate conceptual framework to accomplish either prevention or treatment strategies to tackle pediatric obesity.
生长和发育是儿童期的关键特征，也是健康和充足营养的敏感指标。生命的最初1000天——从受孕到24个月大——是发育的关键时期，因此预防儿童肥胖及其不良后果势在必行。在这个复杂的生命阶段有许多生长驱动因素，如营养、遗传和表观遗传因素以及激素调节。因此，挑战在于在不增加相关疾病风险的情况下，最大限度地发挥正常生长的潜力。地中海营养小组（MeNu小组）是地中海地区的一组研究人员，在本期名为“在生命最初1000天预防肥胖”的特刊中，展示了来自动物模型研究和人类研究的成果，这些成果推动了早期肥胖风险因素科学的发展。未来，预防儿童肥胖的早期干预设计将需要考虑不同的策略，MeNu小组可就适当的概念框架提供指导，以完成预防或治疗儿童肥胖的策略。
