一种多态性单克隆抗体PLM10，可与携带HLA-DPw1、DPw5和DP“Cp63”的B细胞系发生反应。

A polymorphic monoclonal antibody, PLM10, that reacts with B-cell lines carrying HLA-DPw1, DPw5, and DP "Cp63".

作者信息

Maeda H, Hirata R, Hitomi Y, Tohyama H

机构信息

Blood Transfusion Service, Saitama Medical Center, Saitama Medical School, Japan.

出版信息

Tissue Antigens. 1989 Mar;33(3):421-4. doi: 10.1111/j.1399-0039.1989.tb01687.x.

DOI:10.1111/j.1399-0039.1989.tb01687.x

PMID:2787066

Abstract

A monoclonal antibody, PLM10, that reacted with B-cell lines of DPw1, DPw5, and DP "Cp63" phenotypes was produced. The antibody was IgM isotype and efficiently lysed B cells but not T cells from approximately 50% of normal Japanese, raising the possibility of serologic typing of the DP polymorphism by the conventional complement-dependent cytotoxicity test.

摘要

产生了一种单克隆抗体PLM10，它可与DPw1、DPw5和DP“Cp63”表型的B细胞系发生反应。该抗体为IgM同种型，能有效裂解约50%正常日本人的B细胞，但不能裂解T细胞，这增加了通过传统的补体依赖性细胞毒性试验对DP多态性进行血清学分型的可能性。