Wakabayashi Y, Ishiyama T, Sugimoto M, Abe S, Horie S, Matsumoto T, Hirose S
Nihon Ketsueki Gakkai Zasshi. 1989 Feb;52(1):80-5.
In vitro differentiation and proliferation of precursor T-cells was examined in four homosexual men positive for anti-human immunodeficiency virus (HIV), one of whom had acquired immunodeficiency syndrome (AIDS). Peripheral mononuclear cells from the men were cultured with phytohemagglutinin-P in semi-solid culture media containing methylcellulose for 7 days. Colony formation was significantly reduced in all subjects, even in the presence of IL-2. Moreover, numerous colony component cells lacked T-cell specific surface markers. These results suggest that the impaired T-cell differentiation and proliferation occurs at the precursor T-cell level in HIV infection.
对4名抗人类免疫缺陷病毒（HIV）呈阳性的同性恋男性（其中1人患有获得性免疫缺陷综合征，即艾滋病）的前体T细胞的体外分化和增殖情况进行了检测。从这些男性身上获取外周血单个核细胞，与植物血凝素-P一起在含有甲基纤维素的半固体培养基中培养7天。所有受试者的集落形成均显著减少，即便存在白细胞介素-2时也是如此。此外，大量集落组成细胞缺乏T细胞特异性表面标志物。这些结果表明，在HIV感染中，T细胞分化和增殖受损发生在前体T细胞水平。
