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[西多芬与牛血清白蛋白的共轭物对大白鼠生理状态的免疫校正作用]

[Immunocorrection of the physiologic status of white rats by sidnofen conjugates with bovine serum albumin].

作者信息

Danilova R A, Obukhova M F, Sagimbaeva Sh K, Mashkovskiĭ M D, Ashmarin I P

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1989(3):63-9.

PMID:2787172
Abstract

The effect of immunisation by covalent conjugates of known psychostimulant and antidepressant sydnophen with bovine serum albumin (BSA) on behaviour, formation of conditioned reflex reactions and alcoholization of white rats has been studied. The immunization of sydnophen with BSA by conjugates permits to obtain a long-term alteration of the emotional status: suppression of behavioral activity, learning and alcohol attraction of rats similar in some elements to the action of neuroleptic drugs. The direction of these alterations is opposite to ones caused by the action of sydnophen. It gives possibility to consider fruitful the conception on the ways of long-term immunocorrection of the physiological status of organism.

摘要

研究了已知的精神兴奋药和抗抑郁药西地诺芬与牛血清白蛋白(BSA)的共价缀合物对行为、条件反射反应形成以及白鼠酒精化的影响。通过缀合物将西地诺芬与BSA免疫可使情绪状态发生长期改变:抑制行为活动、学习以及白鼠的酒精吸引力,在某些方面类似于抗精神病药物的作用。这些改变的方向与西地诺芬作用所引起的相反。这使得有可能认为关于对机体生理状态进行长期免疫校正方法的概念是有成效的。

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