Katanić Jelena, Matić Sanja, Pferschy-Wenzig Eva-Maria, Kretschmer Nadine, Boroja Tatjana, Mihailović Vladimir, Stanković Vesna, Stanković Nevena, Mladenović Milan, Stanić Snežana, Mihailović Mirjana, Bauer Rudolf
Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia.
Food Chem Toxicol. 2017 Jan;99:86-102. doi: 10.1016/j.fct.2016.11.018. Epub 2016 Nov 18.
Filipendula ulmaria, known as meadowsweet, is a perennial herb found in wild and cultivated habitats in Europe and Asia. Usage of F. ulmaria in traditional medicine is based on diuretic, astringent, antirheumatic, and anti-inflammatory properties of this plant. Exposure to cisplatin at a dose of 7.5 mg/kg caused significant increase in serum parameters of liver and kidneys function and tissue oxidative stress markers along with some histopathological changes in liver and kidney tissues of experimental rats, as well as high level of genotoxicity. Administration of F. ulmaria extracts in three different concentrations (100, 200, and 400 mg/kg/day) for 10 days resulted in a reduction of oxidative stress in tissues and decrease of serum parameters. Moreover, tested extracts attenuated the genotoxicity of cisplatin in reverse dose-dependent manner. F. ulmaria extracts had no in vitro cytotoxic activity at all applied concentrations (IC > 50 μg/mL). Tested extracts, rich in polyphenolic compounds, attenuate cisplatin-induced liver and kidney oxidative stress, reduce tissue damage, and enhance the antioxidative status of experimental animals during cisplatin application. Therefore, F. ulmaria extracts may be used as supportive agent for the prevention and amelioration of cisplatin side effects.
绣线菊，又称绣线菊，是一种多年生草本植物，生长于欧洲和亚洲的野生及人工栽培环境中。绣线菊在传统医学中的应用基于该植物的利尿、收敛、抗风湿和抗炎特性。以7.5毫克/千克的剂量给实验大鼠注射顺铂，会导致其肝脏和肾脏功能的血清参数以及组织氧化应激标志物显著增加，同时肝脏和肾脏组织出现一些组织病理学变化，以及高水平的遗传毒性。以三种不同浓度（100、200和400毫克/千克/天）给予绣线菊提取物10天，可降低组织中的氧化应激并降低血清参数。此外，测试的提取物以剂量依赖性方式减轻了顺铂的遗传毒性。在所有应用浓度（IC>50微克/毫升）下，绣线菊提取物均无体外细胞毒性活性。测试的提取物富含多酚类化合物，可减轻顺铂诱导的肝脏和肾脏氧化应激，减少组织损伤，并在应用顺铂期间增强实验动物的抗氧化状态。因此，绣线菊提取物可作为预防和改善顺铂副作用的辅助剂。
