Bijttebier Sebastiaan, Van der Auwera Anastasia, Voorspoels Stefan, Noten Bart, Hermans Nina, Pieters Luc, Apers Sandra
University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
Flemish Institute for Technological Research (VITO), Business Unit Separation and Conversion Technology (SCT), Mol, Belgium.
Planta Med. 2016 Apr;82(6):559-72. doi: 10.1055/s-0042-101943. Epub 2016 Feb 4.
Filipendula ulmaria (meadowsweet) is traditionally used for the treatment of inflammatory diseases and as a diuretic and antirheumatic. Extracts of Filipendulae herba are on the market in the European Union as food supplements. Nevertheless, its active constituents remain to be revealed. During this study, the phytochemical composition of Filipendulae Ulmariae Herba was comprehensively characterised for the first time with two complementary generic ultrahigh-performance liquid chromatography-photodiode array-accurate mass mass spectrometry methods. Selective ion fragmentation experiments with a hybrid quadrupole-orbital trap mass spectrometer significantly contributed to compound identification: a total of 119 compounds were tentatively identified, 69 new to F. ulmaria. A rich diversity of phenolic constituents was detected and only a few non-phenolic phytochemicals were observed. Metabolisation and pharmacological studies should be conducted to investigate which of these constituents or metabolites there of contribute to the activity of F. ulmaria after oral intake.
绣线菊（绣线菊属植物）传统上用于治疗炎症性疾病，还可作为利尿剂和抗风湿药。绣线菊草提取物在欧盟作为食品补充剂上市。然而，其活性成分仍有待揭示。在本研究中，首次采用两种互补的通用超高效液相色谱 - 光电二极管阵列 - 精确质量质谱法全面表征了绣线菊草的植物化学成分。使用混合四极杆 - 轨道阱质谱仪进行的选择性离子碎裂实验对化合物鉴定有显著帮助：共初步鉴定出119种化合物，其中69种对绣线菊属植物来说是新发现的。检测到丰富多样的酚类成分，仅观察到少数非酚类植物化学成分。应进行代谢和药理研究，以调查这些成分或其代谢产物中哪些在口服后对绣线菊属植物的活性有贡献。
