Kishimoto Jessica, de Ribaupierre Sandrine, Salehi Fateme, Romano Walter, Lee David S C, Fenster Aaron
The University of Western Ontario, Robarts Research Institute, Imaging Research Laboratories, 1151 Richmond Street, London, Ontario N6A 3K7, Canada; The University of Western Ontario, Department of Medical Biophysics, 1151 Richmond Street, London, Ontario N6A 3K7, Canada.
The University of Western Ontario, Department of Medical Biophysics, 1151 Richmond Street, London, Ontario N6A 3K7, Canada; London Health Sciences Centre, Children's Hospital, Department of Paediatrics, 800 Commissioners Road East, London, Ontario N6A 5W9, Canada; London Health Sciences Centre, Department of Clinical Neurological Sciences, 339 Windermere Road, London, Ontario N6A 5A5, Canada.
J Med Imaging (Bellingham). 2016 Oct;3(4):046003. doi: 10.1117/1.JMI.3.4.046003. Epub 2016 Nov 9.
The aim of this study is to compare longitudinal two-dimensional (2-D) and three-dimensional (3-D) ultrasound (US) estimates of ventricle size in preterm neonates with posthemorrhagic ventricular dilatation (PHVD) using quantitative measurements of the lateral ventricles. Cranial 2-D US and 3-D US images were acquired from neonatal patients with diagnosed PHVD within 10 min of each other one to two times per week and analyzed offline. Ventricle index, anterior horn width, third ventricle width, and thalamo-occipital distance were measured on the 2-D images and ventricle volume (VV) was measured from 3-D US images. Changes in the measurements between successive image sets were also recorded. No strong correlations were found between VV and 2-D US measurements ([Formula: see text] between 0.69 and 0.36). Additionally, weak correlations were found between changes in 2-D US measurements and 3-D US VV ([Formula: see text] between 0.13 and 0.02). A trend was found between increasing 2-D US measurements and 3-D US-based VV, but this was not the case when comparing changes between 3-D US VV and 2-D US measurements. If 3-D US-based VV provides a more accurate estimate of ventricle size than 2-D US measurements, moderate-weak correlations with 3-D US suggest that monitoring preterm patients with PHVD using 2-D US measurements alone might not accurately represent whether the ventricles are progressively dilating. A volumetric measure (3-D US or MRI) could be used instead to more accurately represent changes.
本研究的目的是通过对侧脑室的定量测量，比较纵向二维（2-D）和三维（3-D）超声（US）对患有出血后脑室扩张（PHVD）的早产儿脑室大小的估计。对诊断为PHVD的新生儿患者，每周一至两次，在彼此间隔10分钟内采集头颅2-D US和3-D US图像，并进行离线分析。在2-D图像上测量脑室指数、前角宽度、第三脑室宽度和丘脑枕距，从3-D US图像上测量脑室体积（VV）。还记录了连续图像集之间测量值的变化。在VV和2-D US测量值之间未发现强相关性（[公式：见正文]在0.69至0.36之间）。此外，在2-D US测量值的变化与3-D US VV之间发现弱相关性（[公式：见正文]在0.13至0.02之间）。发现2-D US测量值增加与基于3-D US的VV之间存在一种趋势，但在比较3-D US VV和2-D US测量值之间的变化时并非如此。如果基于3-D US的VV比2-D US测量值能更准确地估计脑室大小，与3-D US的中度弱相关性表明，仅使用2-D US测量值监测患有PHVD的早产儿可能无法准确反映脑室是否在逐渐扩张。可以使用体积测量方法（3-D US或MRI）来更准确地反映变化。
