Gribble Fiona M, Diakogiannaki Eleftheria, Reimann Frank
Metabolic Research Laboratories and MRC Metabolic Diseases Unit, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Handb Exp Pharmacol. 2017;236:181-203. doi: 10.1007/164_2016_46.
The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4.
膳食甘油三酯的消化、吸收和利用受肠道激素控制，这些激素由沿胃肠道全长的肠内分泌细胞释放。检测摄入脂质的主要参与者是游离脂肪酸受体FFA1和FFA4，它们在肠内分泌细胞上高度表达。当游离脂肪酸（FFA）通过肠上皮被吸收时，这些受体被激活，并提供一个动态的激素信号，表明脂质正从肠道进入血液。这篇综述阐述了我们目前对于摄入的甘油三酯如何通过FFA1和FFA4调节肠道激素释放的认识。
