GLP-1：一个复杂信号系统的分子机制和结果。
GLP-1: Molecular mechanisms and outcomes of a complex signaling system.
机构信息
Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN, USA.
Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Neurochem Int. 2019 Sep;128:94-105. doi: 10.1016/j.neuint.2019.04.010. Epub 2019 Apr 17.
Abstract
Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Recent work that focused on elucidating the mechanisms and outcomes of GLP-1 neuromodulation led to the discovery of an impressive array of GLP-1 actions. Here, we summarize the many levels at which the GLP-1 signal adapts to different systems, with the goal being to provide a background against which to guide future research.
摘要
进食会引发激素和神经递质的释放，而这些物质反过来又调节能量平衡和进食行为。胰高血糖素样肽-1（GLP-1）就是这样一种激素，由于其强大的肠促胰岛素作用，它在肥胖和糖尿病的治疗中受到了广泛关注。除了 GLP-1 的外周作用外，这种激素还能够通过调节多个神经回路来改变行为。最近的研究工作集中在阐明 GLP-1 神经调节的机制和结果，这导致了对 GLP-1 作用的一系列令人印象深刻的发现。在这里，我们总结了 GLP-1 信号适应不同系统的多个层面，目的是提供一个背景，以指导未来的研究。
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