Tsai T P, Chaux A, Kass R M, Gray R J, Matloff J M
Department of Thoracic and Cardiovascular Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
J Cardiovasc Surg (Torino). 1989 May-Jun;30(3):364-8.
Six hundred and twenty-nine consecutive patients between ages 70 and 79 and 64 patients over age 80 underwent isolated aortocoronary bypass operation with cardiopulmonary bypass. Four hundred and sixty-eight men and 161 women were between ages 70 and 79 (mean 73), and 41 men and 23 women were over age 80 (mean 82). Most patients were in NYHA Functional Class III (septuagenarian 25%, octogenarian 23%) and in Class IV (septuagenarian 59%, octagenarian 72%) preoperatively. Early death was reported in 41 (6.5%) septuagenarians and in 2 (3.1%) octogenarians. Cardiac-related late mortalities were 6.4% and 6.3%, respectively. Five hundred and eighty-eight septuagenarians and 62 octogenarians were over 30-day survivors; 17.5% (sept) and 35.9% (oct) developed major postoperative complications, including bleeding, pericardial tamponade, sternal dehiscence, myocardial infarction, arrhythmia and pump failure. Mean hospital stays were 14.8 and 19 days, respectively. At follow-up (mean 38.2 months) patients had significant functional improvement by one or more classes in 80% and 60%. Mortality was adversely influenced by (1) NYHA Class IV, (2) use of intra-aortic balloon pumping, (3) postoperative hemorrhage, and (4) prolonged ischemic cross-clamp time. This experience indicates that if adequate trial of medical treatment of angina fails in the elderly patient, aortocoronary bypass surgery becomes a successful alternative.
629例年龄在70至79岁之间的连续患者以及64例80岁以上的患者接受了体外循环下的单纯主动脉冠状动脉搭桥手术。年龄在70至79岁之间的有468名男性和161名女性(平均73岁),80岁以上的有41名男性和23名女性(平均82岁)。大多数患者术前处于纽约心脏协会(NYHA)心功能Ⅲ级(70至79岁患者中占25%,80岁以上患者中占23%)和Ⅳ级(70至79岁患者中占59%,80岁以上患者中占72%)。70至79岁患者中有41例(6.5%)、80岁以上患者中有2例(3.1%)报告发生早期死亡。心脏相关的晚期死亡率分别为6.4%和6.3%。588例70至79岁患者和62例80岁以上患者为术后30天以上的幸存者;17.5%(70至79岁患者)和35.9%(80岁以上患者)发生了主要的术后并发症,包括出血、心包填塞、胸骨裂开、心肌梗死、心律失常和泵衰竭。平均住院时间分别为14.8天和19天。在随访(平均38.2个月)时,80%的70至79岁患者和60%的80岁以上患者心功能显著改善一级或更多级别。死亡率受到以下因素的不利影响:(1)NYHAⅣ级,(2)使用主动脉内球囊反搏,(3)术后出血,以及(4)缺血性阻断时间延长。这一经验表明,如果老年患者心绞痛的充分药物治疗试验失败,主动脉冠状动脉搭桥手术是一种成功的替代方法。