Panisset Michel, Picillo Marina, Jodoin Nicolas, Poon Yu-Yan, Valencia-Mizrachi Alejandro, Fasano Alfonso, Munhoz Renato, Honey Christopher R
1Division of Neurology,Department of Medicine,Hôpital Notre-Dame,Centre hospitalier de l'Université de Montréal,Montréal,Québec,Canada.
2Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease,Toronto Western Hospital,University Health Network,Toronto,ON,Canada.
Can J Neurol Sci. 2017 Mar;44(2):132-138. doi: 10.1017/cjn.2016.409. Epub 2016 Nov 22.
During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to share their knowledge regarding deep brain stimulation (DBS) management of movement disorders in three domains: (1) the programming algorithms, (2) the necessary team to run a neurosurgery program, and (3) the appropriate scales to better define in a more comprehensive fashion the effect of the brain surgery. Each presentation was followed by an open discussion, and this article reports on the conclusions of this meeting on these three questions. Concerning programming, the role of the pulse width and the switching off of the stimulation at night for thalamic stimulation for the control of tremor have been discussed. The algorithms proposed in the literature for programming in Parkinson's disease (PD) need validation. In dystonia, the use of monopolar vs bipolar parameters, the use of low vs high frequencies and the use of smaller versus larger pulse widths all need to be examined properly. Concerning the necessary team to run a neurosurgical program, recommendations will follow the suggestions for standardized outcome measures. Regarding the outcome measures for DBS in PD, investigations need to focus on the non-motor aspects of PD. Identifying which nonmotor symptoms respond to DBS would allow a better screening before and satisfaction postoperatively. There is an important need for more data to determine the optimal programming protocol and the standard measures that should be performed routinely by all centers.
在2014年7月4日至5日于多伦多举行的“加拿大脑深部电刺激日”研讨会上,科学委员会邀请专家就运动障碍的脑深部电刺激(DBS)管理在三个领域分享他们的知识:(1)编程算法,(2)开展神经外科项目所需的团队,以及(3)更全面地更好定义脑部手术效果的合适量表。每场报告之后都进行了开放讨论,本文报道了此次会议关于这三个问题的结论。关于编程,已讨论了脉冲宽度的作用以及夜间关闭丘脑刺激以控制震颤的问题。文献中提出的用于帕金森病(PD)编程的算法需要验证。在肌张力障碍中,单极与双极参数的使用、低频与高频的使用以及较小与较大脉冲宽度的使用都需要进行适当研究。关于开展神经外科项目所需的团队,建议将遵循标准化结局指标的相关建议。关于PD中DBS的结局指标,研究需要聚焦于PD的非运动方面。确定哪些非运动症状对DBS有反应将有助于术前更好地筛选以及术后提高满意度。迫切需要更多数据来确定最佳编程方案以及所有中心都应常规执行的标准测量方法。