用于灵敏检测肽的聚合物介导的三元超分子相互作用
Polymer-mediated ternary supramolecular interactions for sensitive detection of peptides.
作者信息
Serrano Mahalia A C, He Huan, Zhao Bo, Ramireddy Rajasekhar R, Vachet Richard W, Thayumanavan S
机构信息
Department of Chemistry, University of Massachusetts, Amherst, MA 01003-9336, USA.
出版信息
Analyst. 2016 Dec 19;142(1):118-122. doi: 10.1039/c6an01591c.
Abstract
A combination of donor-acceptor and electrostatic interactions in a three-component supramolecular system has been shown to form the basis for selective and sensitive detection of peptides. Different substituents in the polymer and the detection matrix were compared to demonstrate that the favorable donor-acceptor interactions explain the observed signal enhancement. The ternary supramolecular interactions discovered in this work are enabled by the self-packing behavior of amphiphilic homopolymers and their ability to mediate interactions between the detection matrix and peptide that facilitate sensitive detection of peptides.
摘要
在一个三组分超分子体系中，供体-受体相互作用和静电相互作用的结合已被证明是肽选择性和灵敏检测的基础。对聚合物和检测基质中的不同取代基进行了比较，以证明有利的供体-受体相互作用解释了观察到的信号增强。这项工作中发现的三元超分子相互作用是由两亲性均聚物的自组装行为及其介导检测基质与肽之间相互作用的能力实现的，这些相互作用有助于肽的灵敏检测。
相似文献
1
Polymer-mediated ternary supramolecular interactions for sensitive detection of peptides.
Analyst. 2016 Dec 19;142(1):118-122. doi: 10.1039/c6an01591c.
2
Matrix-assisted laser desorption ionization-mass spectrometry signal enhancement of peptides after selective extraction with polymeric reverse micelles.
Anal Chem. 2010 May 1;82(9):3686-91. doi: 10.1021/ac1000256.
3
Supramolecular Ensembles Formed between Charged Conjugated Polymers and Glycoprobes for the Fluorogenic Recognition of Receptor Proteins.
ACS Appl Mater Interfaces. 2016 Jun 1;8(21):13601-6. doi: 10.1021/acsami.6b03223. Epub 2016 May 17.
4
Amphiphilic peptide-polymer conjugates with side-conjugation.
Macromol Rapid Commun. 2011 Feb 16;32(4):344-53. doi: 10.1002/marc.201000603. Epub 2011 Jan 27.
5
Electrostatic control of peptide side-chain reactivity using amphiphilic homopolymer-based supramolecular assemblies.
J Am Chem Soc. 2013 Sep 25;135(38):14179-88. doi: 10.1021/ja404940s. Epub 2013 Sep 11.
6
Time-resolved energy transfer in DNA sequence detection using water-soluble conjugated polymers: the role of electrostatic and hydrophobic interactions.
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11634-9. doi: 10.1073/pnas.0404574101. Epub 2004 Jul 28.
7
Self-assemblies of amphiphilic homopolymers: synthesis, morphology studies and biomedical applications.
Chem Commun (Camb). 2015 Jul 25;51(58):11541-55. doi: 10.1039/c5cc03016a. Epub 2015 Jun 15.
8
Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles.
Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):3954-9. doi: 10.1073/pnas.1517169113. Epub 2016 Mar 28.
9
Hierarchical Assemblies of Supramolecular Coordination Complexes.
Acc Chem Res. 2018 Sep 18;51(9):2047-2063. doi: 10.1021/acs.accounts.8b00233. Epub 2018 Aug 22.
10
Phase equilibria, solvent properties, and protein partitioning in aqueous polyethylene glycol-600-trimethylamine N-oxide and polyethylene glycol-600-choline chloride two-phase systems.
J Chromatogr A. 2018 Feb 2;1535:154-161. doi: 10.1016/j.chroma.2018.01.010. Epub 2018 Jan 3.
引用本文的文献
1
Sequential Nucleophilic "Click" Reactions for Functional Amphiphilic Homopolymers.
Polym Chem. 2019 Jan 14;10(2):187-193. doi: 10.1039/C8PY01341A. Epub 2018 Nov 15.
2
Absolute Quantitation of Oxidizable Peptides by Coulometric Mass Spectrometry.
J Am Soc Mass Spectrom. 2019 Nov;30(11):2398-2407. doi: 10.1007/s13361-019-02299-z. Epub 2019 Aug 19.
3
Supramolecular Polymeric Assemblies for the Selective Depletion of Abundant Acidic Proteins in Serum.
ACS Appl Mater Interfaces. 2018 Nov 28;10(47):40443-40451. doi: 10.1021/acsami.8b15976. Epub 2018 Nov 15.
4
Self-assembly of random co-polymers for selective binding and detection of peptides.
Polym Chem. 2018 Mar 7;9(9):1066-1071. doi: 10.1039/C7PY01947E. Epub 2017 Dec 19.
5
Improved mass spectrometric detection of acidic peptides by variations in the functional group pK values of reverse micelle extraction agents.
Analyst. 2018 Mar 12;143(6):1434-1443. doi: 10.1039/c7an02094e.
6
Altering the Peptide Binding Selectivity of Polymeric Reverse Micelle Assemblies via Metal Ion Loading.
Langmuir. 2017 Dec 12;33(49):14004-14010. doi: 10.1021/acs.langmuir.7b02488. Epub 2017 Aug 31.
本文引用的文献
1
Cucurbituril-Based Molecular Recognition.
Chem Rev. 2015 Nov 25;115(22):12320-406. doi: 10.1021/acs.chemrev.5b00341. Epub 2015 Nov 13.
2
Argonaute proteins: functional insights and emerging roles.
Nat Rev Genet. 2013 Jul;14(7):447-59. doi: 10.1038/nrg3462. Epub 2013 Jun 4.
3
Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis.
Anal Chem. 2012 May 1;84(9):4237-43. doi: 10.1021/ac300540r. Epub 2012 Apr 16.
4
One-step fabrication of supramolecular microcapsules from microfluidic droplets.
Science. 2012 Feb 10;335(6069):690-4. doi: 10.1126/science.1215416.
5
Selective enrichment and sensitive detection of peptide and protein biomarkers in human serum using polymeric reverse micelles and MALDI-MS.
Analyst. 2012 Feb 21;137(4):1024-30. doi: 10.1039/c2an16089g. Epub 2011 Dec 23.
6
Molecular design and ordering effects in π-functional materials for transistor and solar cell applications.
J Am Chem Soc. 2011 Dec 21;133(50):20009-29. doi: 10.1021/ja2073643. Epub 2011 Nov 22.
7
Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry.
Rapid Commun Mass Spectrom. 2011 Mar 15;25(5):639-46. doi: 10.1002/rcm.4903.
8
Selective enrichment and analysis of acidic peptides and proteins using polymeric reverse micelles and MALDI-MS.
Anal Chem. 2010 Oct 15;82(20):8686-91. doi: 10.1021/ac101922b.
9
Supramolecular cross-linked networks via host-guest complexation with cucurbit[8]uril.
J Am Chem Soc. 2010 Oct 13;132(40):14251-60. doi: 10.1021/ja106362w.
10
Matrix-assisted laser desorption ionization-mass spectrometry signal enhancement of peptides after selective extraction with polymeric reverse micelles.
Anal Chem. 2010 May 1;82(9):3686-91. doi: 10.1021/ac1000256.
Zotero 插件