Department of Chemical Engineering, Widya Mandala Catholic University, Surabaya, Indonesia.
Nanotechnology. 2016 Dec 16;27(50):505605. doi: 10.1088/0957-4484/27/50/505605. Epub 2016 Nov 22.
In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100-200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur). The bioavailability of MSN-A-Cur and MSM-A-Cur was considerably higher than that of 'free curcumin'. These results indicate promising features of amine functionalized MSN as a carrier to deliver low solubility drugs with improved bioavailability via the oral route.
在本工作中，采用了一种简单的方法来制备姜黄素-胺功能化介孔硅纳米粒子（MSN）复合材料。通过口服给药，利用纳米粒子来提高姜黄素在小鼠体内的生物利用度。我们研究了粒径对姜黄素在小鼠体内的释放特性、溶解度和口服生物利用度的影响，包括胺功能化介孔硅微米级粒子（MSM）和 MSN（100-200nm）。与胺 MSM（MSM-A-Cur）相比，载于胺功能化 MSN（MSN-A-Cur）内的姜黄素具有更好的释放特性和更高的溶解度。MSN-A-Cur 和 MSM-A-Cur 的生物利用度明显高于“游离姜黄素”。这些结果表明，胺功能化 MSN 作为载体具有很大的应用潜力，可通过口服途径递送低溶解度药物，提高其生物利用度。
