Juliato P T, Rodrigues A T, Stahlschmidt R, Juliato C R T, Mazzola P G
a Postgraduate Program in Biosciences and Technology of Bioactive Products , Institute of Biology, State University of Campinas , Brazil.
b Postgraduate Program in Medical Sciences , State University of Campinas , Brazil.
Climacteric. 2017 Feb;20(1):62-66. doi: 10.1080/13697137.2016.1258396. Epub 2016 Nov 23.
There is a lack of safety data supporting the use of hormone therapy in women who have had breast cancer and who have complained of genitourinary syndrome of menopause (GSM). The objective was to test the efficacy of two non-hormonal therapies for vaginal dryness.
This was a randomized trial with 52 women with breast cancer who were being treated with tamoxifen and who complained of vaginal dryness. The volunteers answered two questionnaires to evaluate sexual function (Female Sexual Function Index, FSFI) and a customized GSM questionnaire. The women were randomized into two groups: 25 (48.1%) in the polyacrylic acid group and 27 (51.9%) in the lubricant group, using either one of the treatments for 30 days, and after they were invited to answer the questionnaires again.
There was improvement in the FSFI after both treatments. The polyacrylic acid group showed a decrease in sexual dysfunction from 96% to 24% (p < 0.0001) and the lubricant group showed a decrease from 88.9% to 55.6% (p = 0.0027).
The results of this study showed that both treatments improved sexual function; however, polyacrylic acid was superior to the lubricant in treating sexual dysfunction.
缺乏安全性数据支持在患有乳腺癌且有更年期泌尿生殖综合征（GSM）症状的女性中使用激素疗法。目的是测试两种非激素疗法治疗阴道干燥的疗效。
这是一项随机试验，52名正在接受他莫昔芬治疗且有阴道干燥症状的乳腺癌女性参与。志愿者回答两份问卷以评估性功能（女性性功能指数，FSFI）和一份定制的GSM问卷。这些女性被随机分为两组：聚丙烯酸组25名（48.1%），润滑剂组27名（51.9%），使用其中一种治疗方法30天，之后再次邀请她们回答问卷。
两种治疗后FSFI均有改善。聚丙烯酸组性功能障碍从96%降至24%（p < 0.0001），润滑剂组从88.9%降至55.6%（p = 0.0027）。
本研究结果表明，两种治疗均改善了性功能；然而，在治疗性功能障碍方面，聚丙烯酸优于润滑剂。
