Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Clin Chim Acta. 2017 Jan;464:160-164. doi: 10.1016/j.cca.2016.11.030. Epub 2016 Nov 19.
Müller Stem cells to treat ocular diseases has triggered enthusiasm across all medical and scientific communities. Recent development in the field of stem cells has widened the prospects of applying cell based therapies to regenerate ocular tissues that have been irreversibly damaged by disease or injury. Ocular tissues such as the lens and the retina are now known to possess cell having remarkable regenerative abilities. Recent studies have shown that the Müller glia, a cell found in all vertebrate retinas, is the primary source of new neurons, and therefore are considered as the cellular basis for retinal regeneration in mammalian retinas. Here, we review the current status of retinal regeneration of the human eye by Müller stem cells. This review elucidates the current status of retinal regeneration by Müller stem cells, along with major retinal degenerative diseases where these stem cells play regenerative role in retinal repair and replacement.
Müller 干细胞治疗眼部疾病在所有医学和科学界都引发了热情。干细胞领域的最新发展拓宽了应用基于细胞的疗法来再生已被疾病或损伤不可逆破坏的眼部组织的前景。现在已知眼部组织（如晶状体和视网膜）具有显著的再生能力。最近的研究表明，Müller 胶质细胞，一种存在于所有脊椎动物视网膜中的细胞，是新神经元的主要来源，因此被认为是哺乳动物视网膜再生的细胞基础。在这里，我们综述 Müller 干细胞对人眼视网膜再生的现状。本综述阐明了 Müller 干细胞对视网膜再生的现状，以及这些干细胞在主要的视网膜退行性疾病中在视网膜修复和替代中发挥再生作用的情况。
