Abarca-Buis René Fernando, Mandujano-Tinoco Edna Ayerim, Cabrera-Wrooman Alejandro, Krötzsch Edgar
Laboratory of Connective Tissue, Centro Nacional de Investigación y Atención de Quemados, Instituto Nacional de Rehabilitación "Luís Guillermo Ibarra Ibarra", Calzada México-Xochimilco No. 289, Col. Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico.
J Cell Commun Signal. 2021 Mar;15(1):7-23. doi: 10.1007/s12079-021-00605-7. Epub 2021 Jan 22.
The role of transforming growth factor β TGFβ/activin signaling in wound repair and regeneration is highly conserved in the animal kingdom. Various studies have shown that TGF-β/activin signaling can either promote or inhibit different aspects of the regeneration process (i.e., proliferation, differentiation, and re-epithelialization). It has been demonstrated in several biological systems that some of the different cellular responses promoted by TGFβ/activin signaling depend on the activation of Smad-dependent or Smad-independent signal transduction pathways. In the context of regeneration and wound healing, it has been shown that the type of R-Smad stimulated determines the different effects that can be obtained. However, neither the possible roles of Smad-independent pathways nor the interaction of the TGFβ/activin pathway with other complex signaling networks involved in the regenerative process has been studied extensively. Here, we review the important aspects concerning the TGFβ/activin signaling pathway in the regeneration process. We discuss data regarding the role of TGF-β/activin in the most common animal regenerative models to demonstrate how this signaling promotes or inhibits regeneration, depending on the cellular context.
转化生长因子β（TGFβ）/激活素信号通路在伤口修复和再生中的作用在动物界高度保守。各种研究表明，TGF-β/激活素信号通路既可以促进也可以抑制再生过程的不同方面（即增殖、分化和再上皮化）。在多个生物系统中已经证明，TGFβ/激活素信号通路促进的一些不同细胞反应取决于Smad依赖性或Smad非依赖性信号转导通路的激活。在再生和伤口愈合的背景下，已经表明受刺激的R-Smad类型决定了可能获得的不同效果。然而，Smad非依赖性通路的可能作用以及TGFβ/激活素通路与再生过程中涉及的其他复杂信号网络的相互作用都尚未得到广泛研究。在这里，我们综述了再生过程中TGFβ/激活素信号通路的重要方面。我们讨论了关于TGF-β/激活素在最常见的动物再生模型中的作用的数据，以证明这种信号通路如何根据细胞环境促进或抑制再生。
