Hogg N
Immunol Today. 1989 Apr;10(4):111-4. doi: 10.1016/0167-5699(89)90238-7.
During the 1980s, various laboratories identified a rare type of patient suffering from recurrent bacterial infections whose neutrophils showed reduced spreading on surfaces. Such leukocyte adhesion deficient (LAD) patients were shown to lack a trio of molecules named either LFA-1, CR3/Mac-1/Mo1, p150,95/CR4 or CD11, CD18 or the leukocyte integrin family. In September 1988, the first meeting exclusively devoted to this topic was held.
在20世纪80年代，各个实验室发现了一类罕见的患者，他们反复遭受细菌感染，其嗜中性粒细胞在表面的铺展能力下降。这类白细胞黏附缺陷（LAD）患者被证实缺乏一组名为LFA-1、CR3/Mac-1/Mo1、p150,95/CR4或CD11、CD18的分子，即白细胞整合素家族。1988年9月，首次专门针对该主题的会议召开。
