两种包虫囊肿抗原对C57/黑小鼠黑色素瘤生长的影响。
Effect of two hydatid cyst antigens on the growth of melanoma cancer in C57/black mice.
作者信息
Chookami Milad Badri, Sharafi Seyedeh Maryam, Sefiddashti Raheleh Rafiei, Jafari Rasool, Bahadoran Mehran, Pestechian Nader, Yousofi Darani Hossein
机构信息
Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Parasit Dis. 2016 Dec;40(4):1170-1173. doi: 10.1007/s12639-015-0643-7. Epub 2015 Feb 28.
Abstract
Hydatid cyst is the larval stage of . In previous studies inhibitory effect of this parasite on cancer cell growth in culture medium has been shown. In this study effect of hydatid cyst antigens on tumor growth in experimental animals has been investigated. Two antigens of hydatid cyst including protoscolices excretory secretory antigen and hydatid fluid absorbed on alum as adjuvant were injected to two groups of C57/black mice as case groups. Control groups were injected with only saline and alum. All mice then were injected with melanoma cells. Both antigens reduced the tumor size in mice in case groups. The difference of tumor size in mice in case groups and control group was statistically significant. In conclusion, anti-tumor effect of hydatid cyst antigens may be related to antigenic similarities which exist between hydatid cyst and cancer cells.
摘要
包虫囊肿是……的幼虫阶段。在先前的研究中，已表明这种寄生虫对培养基中癌细胞生长具有抑制作用。在本研究中，研究了包虫囊肿抗原对实验动物肿瘤生长的影响。将两种包虫囊肿抗原，即原头节排泄分泌抗原和吸附在明矾上作为佐剂的包虫液，注射到两组C57/黑小鼠作为病例组。对照组仅注射生理盐水和明矾。然后给所有小鼠注射黑色素瘤细胞。两种抗原均减小了病例组小鼠的肿瘤大小。病例组和对照组小鼠的肿瘤大小差异具有统计学意义。总之，包虫囊肿抗原的抗肿瘤作用可能与包虫囊肿和癌细胞之间存在的抗原相似性有关。
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