Sharafi Seyedeh Maryam, Sefiddashti Raheleh Rafiei, Sanei Behnam, Yousefi Morteza, Darani Hossein Yousofi
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2017 Aug 16;22:92. doi: 10.4103/jrms.JRMS_1030_16. eCollection 2017.
Hydatid cyst is the larval stage of dog tape worm . Protoscolices are parasite larvae that develop into adult worms in the final host intestine. During surgical treatment of human hydatidsosis spillage of live protoscolices is the major cause of hydatidosis recurrence. To prevent this problem scolicidal agent such as hypertonic salt are used to kill the protoscolices that may disseminate into the patient's tissues during surgery. However, they may have some unacceptable side effects. To find scolicidal agents with high efficacy, the effect of different compounds on protoscolices of hydatid cyst has been reviewed. Using PubMed, Scopus, Google Scholar, and SID databases articles about scolicidal effects of different agents on protoscolices of hydatid cyst were collected. after 5 min, metalonic extracts of and hypertonic saline after 10 min, and warm water after 2 min kill all alive protoscolices. The above agents that in minimum time and minimum concentration have 100% scolicidal activity, could be good candidates for further investigations.
包虫囊肿是犬绦虫的幼虫阶段。原头蚴是寄生虫幼虫，可在终宿主肠道内发育为成虫。在人类包虫病的外科治疗过程中，活原头蚴的溢出是包虫病复发的主要原因。为防止这一问题，人们使用诸如高渗盐等杀头节剂来杀死手术过程中可能扩散到患者组织中的原头蚴。然而，它们可能会有一些不可接受的副作用。为了找到高效的杀头节剂，本文综述了不同化合物对包虫囊肿原头蚴的作用。利用PubMed、Scopus、谷歌学术和SID数据库，收集了关于不同药剂对包虫囊肿原头蚴杀头节作用的文章。5分钟后，[具体物质]的金属提取物、10分钟后的高渗盐水以及2分钟后的温水可杀死所有活的原头蚴。上述能在最短时间和最低浓度下具有100%杀头节活性的药剂，可能是进一步研究的良好候选者。
