Li Hongde, Liu Sufang, Hu Jianmin, Luo Xiangjian, Li Namei, M Bode Ann, Cao Ya
Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China; Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha 410078, China.
Division of Hematology, Institute of Molecular Hematology, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Int J Biol Sci. 2016 Oct 18;12(11):1309-1318. doi: 10.7150/ijbs.16564. eCollection 2016.
Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies.
爱泼斯坦-巴尔病毒（EBV）与多种人类癌症相关。在宿主体内，EBV可建立两种不同的生命周期模式，即潜伏或裂解，从潜伏期转变为裂解周期被称为EBV再激活。尽管癌细胞中的EBV大多处于潜伏期，但少数被裂解感染的细胞通过释放生长因子和致癌细胞因子促进致癌作用。本综述重点关注细胞和病毒因素控制EBV再激活的机制，并讨论EBV裂解感染如何导致人类恶性肿瘤。
