Miki S, Iwano M, Miki Y, Yamamoto M, Tang B, Yokokawa K, Sonoda T, Hirano T, Kishimoto T
Third Department of Internal Medicine, Nissei Hospital, Osaka, Japan.
FEBS Lett. 1989 Jul 3;250(2):607-10. doi: 10.1016/0014-5793(89)80805-1.
Interleukin-6 (IL-6) was found to be a growth factor of renal cell carcinomas Furthermore, renal cell carcinomas freshly isolated from the patients expressed mRNA of IL-6 and secreted biologically active IL-6 under the culture conditions where the tumor cells could grow, but they did not produce IL-6 nor proliferate in the absence of fetal calf serum. The production of IL-6 by the tumor cells was also demonstrated by immunostaining of the IL-6-producing cells utilizing anti-IL-6 antiserum. Moreover, anti-IL-6 antiserum specifically inhibited the in vitro tumor growth. All data indicated that IL-6 functions as an in vitro autocrine growth factor of renal cell carcinomas.
白细胞介素-6（IL-6）被发现是肾细胞癌的一种生长因子。此外，从患者体内新鲜分离出的肾细胞癌在肿瘤细胞能够生长的培养条件下表达IL-6的mRNA并分泌具有生物活性的IL-6，但在没有胎牛血清的情况下，它们不产生IL-6也不增殖。利用抗IL-6抗血清对产生IL-6的细胞进行免疫染色也证实了肿瘤细胞产生IL-6。此外，抗IL-6抗血清特异性抑制体外肿瘤生长。所有数据表明，IL-6作为肾细胞癌的一种体外自分泌生长因子发挥作用。
